Identification of attenuation markers of a Theileria lestoquardi cell line to be used for the development of live vaccine against malignant ovine theileriosis
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چکیده
Identification of attenuation markers of a Theileria lestoquardi cell line to be used for the development of live vaccine against malignant ovine theileriosis Inaugural-Dissertation zur Erlangung der tiermedizinischen Doktorwürde
منابع مشابه
The first genetic identification of Theileria ovis subtype KP019206 in sheep in Iran
Ticks and tick-borne diseases, including theileriosis, constitute a major constraint to livestock production. Two species, known as Theileria lestoquardi and Theileria ovis, are suspected to contribute to ovine theileriosis in Iran. However, the epidemiological aspects of ovine theileriosis are poorly understood in this country. In a survey, designed to identify Theileria species in sheep, 52 (...
متن کاملIdentification of Theileria species in sheep in the eastern half of Iran using nested PCR-RFLP and microscopic techniques
Theileria species are common in tropical and subtropical regions and cause great economical losses inruminants. Two species, T. lestoquardi and T. ovis, are suspected to cause ovine theileriosis in Iran. Theepidemiological aspects of ovine theileriosis in Iran are poorly understood and further investigations bysensitive and precise techniques are required. In a previous study, a sensitive and s...
متن کاملSemi-quantitative Analysis of Expression of Various Genes in relation to Possible Markers for Theileria annulata Attenuation
The sporozoites of Theileria annulata invade bovine MHC II cells, where they differentiate into schizonts. The later can immortalize and induce fundamental changes in their host cells. Live attenuated vaccine is an important way of controlling T. annulata infection of cattle. Production is by prolonged cultivation of macroschizont-infected cells. The mechanisms underlying this transformation ...
متن کاملMalignant Ovine Theileriosis (Theileria lestoquardi): A Review
Malignant Ovine Theileriosis (MOT) is a tick borne disease of sheep and goats, caused by Theileria lestoquardi and is considered a major constraint for sheep production in many areas of the world. It has been reported to infect lymphocytes in vivo and in vitro and the schizonts differentiate into macro-schizonts and micro-schizonts. To date, little is known about the mechanisms involved in the ...
متن کاملIn silico analysis of Ta9 gene polymorphism in an Iranian Theileria annulata schizont-infected cell line S15 vaccine strain and native isolates
Bovine theileriosis is a tick-borne disease caused by obligate intracellular parasites related to the genus Theileria. Cellular immune responses protect cattle against pathogens through the activation of immune cells. Nowadays, live, attenuated vaccine of Theileria annulata (T. annulata) is being produced in Iran and is recommended for active cattle immunization. Detection of the immunogenic a...
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